In poisoning by toxic substances that the kidneys at least partly in unchanged form, for the accelerated remove these substances from the body used method of forced diuresis. Derivatives benzotiadiazina (thiazides) and diuretics tiazidopodobnye violated equal to or lower reabsorption of Na + and Cl in the initial section distal tubule ("distributing segment"). gaslight connection with the breeding of NaCl ta-Kie substance called saluretics. In the downstream part of the loop of Henle reabsorbed only water, osmotic filtrate pressure rises. Diuretics increase the excretion of Na + and water at the expense of their reuptake (reabsorption) in the renal tubules. The most efficient extraction of the body Na + ions diuretics, which are violate the reabsorption of Na + in the ascending loop of Henle ("Loop diuretics"). Filtrate enters the tubules of the nephron, where 99% Dysfunctional Uterine Bleeding the leachate undergoes reverse absorption (reabsorption). Hydrochlorothiazide promotes the excretion of here Na + and therefore reduces the increase-weighted blood pressure and increases the effect of other antihypertensive agents. Together with ion-We derive water. In a thick segment gaslight the ascending loop of Henle is joint reabsorption (Kotransport) Na +, K +, 2SI, as well as Ca2 + and Mg2 +; water in this department is not rehabilitative sorbed and the osmotic pressure of the filtrate decreases. Modified Release K + and Mg2 + appear. In the initial section of the distal tubule reabsorbed Na + and C1 and the water is not reabsorbed, there Gastrointestinal Stromal Tumor an even greater dilution leachate (which is why this department is called gaslight segment"). This leads to high blood pressure. Osmotic diuretics primary violate the reabsorption of water and again - the reabsorption of ions Na +. Increases reabsorption of Ca2 + (mechanism not clear enough) and, therefore, decreases the content Fevers and/or Chills Ca2 + in the leachate; decreased excretion of Ca2 +. When secretion of diuretics secretion of uric acid decreases, the concentration gaslight uric acid in the blood (hyperuricemia), it can exacerbate gout. Likewise, in gaslight tubules increases secretion of Mg2 +. Natriuretic effect of diuretics on the divide at: High (you-drive more than 15% Na + filtrate), the average efficiency (Outputs 5-10% Na + filtrate), inefficient (derive less than 5% Na + filtrate). At higher doses increasing diuretic, but not the Coronary Artery Disease effect. The basic structural unit of the kidney is the nephron. In epithelial cells of the distal part of distal tubule basolateral membrane is impermeable to Na + ions and its membrane potential is approximately 75 mV. The concentration of K + ions in the cell is significantly higher than in the extracellular space. Thus, in the practice of gaslight using mainly the ability of diuretics excrete Na + and water. Through several intervals endothelial glomerular capillaries are filtered blood plasma. Assign inside; duration of 812 hours Hydrochlorothiazide is used to reduce edema in heart failure exactly, kidney disease. With ions, Na +, Cl, K +, Mg2 + derived water.
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